The invention relates to an antitheft backpack with multiple conductive materials being embedded into zipper teeth. The antitheft backpack comprises a backpack body with an opening, a conductive zipper, an alarm module and a power supply module, wherein the conductive zipper comprises zipper chains, the zipper teeth and two zipper pullers; first sides, opposite to other zipper teeth, of the front ends of the zipper teeth are provided with contact protrusions, and contact holes are formed in second sides opposite to the first sides; the zipper teeth are made of insulating materials, the multiple conductive materials which are not connected are embedded into the front ends of the zipper teeth to form conductive parts which are exposed from the contact protrusions and the contact holes, the two zipper pullers are oppositely arranged on the zipper chains, and the zipper teeth are meshed under the action of the zipper pullers to form a conductive wire. The antitheft backpack has the advantages that a traditional zipper is changed into the conductive zipper and turned into a sensor at the same time; when the zipper pullers are separated, the conductive zipper is disconnected, an alarm gives out an alarm, other people are prevented from privately opening the backpack without the consent of a user, and an antitheft effect is achieved.