13 results about "Piperazine" patented technology

The present invention discloses one kind of aryl formyl piperazine compound and its preparation process and application in preparing medicine. The compound and its medicinal salt have the general expressions shown. The compound may be used in preparing medicine for arrhythmia. The compound has rich material source, mild reaction condition and simple preparation process and post-treatment.

The invention discloses a halogen-free flame retardant and a preparation method thereof and a flame-retardant polyolefin composition composed of the same. The structural formula of the halogen-free flame retardant is shown in the description, wherein the ratio of x to y to z is 1:(5-10):(1-5). The preparation method comprises the steps that melamine, phosphoric acid and piperazine are weighed and put into a high-speed mixer of which the top is provided with a liquid spray device to be stirred and mixed to be uniform, and a halogen-free flame retardant premixed material is obtained; the halogen-free flame retardant premixed material is subjected to a high-temperature dehydration condensation reaction, and the polyphosphoric acid-melamine-piperazine composite salt halogen-free flame retardant is obtained. The halogen-free flame retardant with the composite salt structure has the advantages that the halogen-free flame retardant is good in heat stability, high in phosphorus content and free of impurities such as halogens and inorganic salts, and the index of whiteness is larger than 90; few synthesizing process steps are needed, operation is simple and easy to carry out, the requirement on equipment is low, and the product yield reaches up to 80% or above; the flame-retardant polyolefin composition containing the halogen-free flame retardant has the good flame-retardant property, high water-resistant and heat-resistant properties and the excellent pigmenting property.

The invention discloses a coproduction method of 1, 2-propanediamine and dimethyl piperazine, which comprises the following steps of: mixing ammonia and isopropanol amine, pre-heating for vaporization, filling steam into a fixed-bed reactor, performing reaction in the presence of a catalyst for condensation and amination and under conditions with the pressure of 1.0MPa to 4.0MPa, the temperature of 300 DEG C to 350 DEG C and the contact time of 1.0-3.0s to obtain product stream of 1, 2-propanediamine, 2, 5-dimethyl piperazine, 2, 6-dimethyl piperazine, unreacted ammonia and unreacted isopropanol amine, and distilling the product stream for separation to obtain the 1, 2-propanediamine, 2, 5-dimethyl piperazine and 2, 6-dimethyl piperazine; wherein the weight ratio of the ammonia and the isopropanol amin is (10-16):1, and the catalyst for condensation and amination comprises the following ingredients by weight percentage: 97-99 percent of HZSM-5 (H-type zeolite sieve of molecular porosity 5) zeolite and 1-3 percent of phosphorus. The coproduction method is mainly applied in preparation of the 1, 2-propanediamine and the dimethyl piperazine.

The invention discloses an organic corrosion inhibitor for inhibiting magnesium alloy corrosion and an application method of the organic corrosion inhibitor in an automobile cooling liquid or a corrosion aqueous solution. The corrosion inhibitor consists of the components in percentage by weight: 10-90 percent of pyrazine or/and piperazine and 10-90 percent of water or/and ethanol. According to the application method, the corrosion inhibitor is added into the automobile cooling liquid or the corrosion aqueous solution which immerses a magnesium alloy according to an adding amount of 50-1,000 ppm under a condition at the temperature of -50-90 DEG C. The using amount of the corrosion inhibitor disclosed by the invention is small; the corrosion inhibitor is high in corrosion inhibition efficiency and good in corrosion inhibition effect; under normal temperature, the corrosion inhibition rate can be over 90 percent. The corrosion inhibitor is organic, so that the common shortcomings of an inorganic corrosion inhibitor are overcome; the application temperature range is wide; the organic corrosion inhibitor is applicable to low temperature and normal temperature and can still effectively inhibit corrosion of the magnesium alloy in a solution medium with higher temperature, and the corrosion inhibition rate can be over 80 percent under the higher temperature. The corrosion inhibitor product disclosed by the invention has the advantages of simplicity in production, wide application range, no toxicity, no peculiar smell, complete water solubility, safety and convenience in operation, good economical property and the like.

The invention discloses a preparation method of a polytriazine alkali-resistant composite nanofiltration membrane. The alkali-resistant composite nanofiltration membrane is composed of a porous base membrane playing a supporting role and an ultrathin surface layer, the ultra-thin surface layer is prepared by the following steps: performing interfacial polymerization crosslinking reaction on a polyfunctional group crosslinking agent capable of reacting with amido (primary amine or secondary amine) and a triazine compound with at least two or more amido (primary amine or secondary amine) to form a nascent state nanofiltration membrane, and then performing post-crosslinking by adopting a novel crosslinking agent. According to the preparation method of the polytriazine alkali-resistant composite nanofiltration membrane, the nanofiltration membrane has excellent separation performance, compared with a traditional polypiperazine amide nanofiltration membrane, the alkali resistance of the nanofiltration membrane can be effectively improved through a unique triazine aromatic cross-linked structure, and the membrane can be suitable for systems such as decoloration and saline water separation.

A 7-[4-[4-(2,3-dichlorophenyl)-1-piperazine]-2- butenoxy]-3,4-dihydro-2-(1H)-quinoline-2-one and its receptable salt, its preparing process featuring use of high-activity, 1,4-dibromo-2-butene to replace 1,4-bibromobutane, its application in preparing aripiperazole and the process for preparing aripiperazole are disclosed.

The invention discloses a novel charged nanofiltration membrane for removing organic matter and a preparation method of the novel charged nanofiltration membrane. The preparation method comprises the following steps: (1) dissolving polysulfone resin into a mixture of DMF and ethylene glycol, and conducting stirring and degassing to obtain a resin membrane casting solution; (2) coating a non-woven fabric with the resin membrane casting solution, and performing phase inversion in deionized water to form pores, so as to obtain a porous polysulfone-based membrane; (3) preparing any one of a disodium hydrogen phosphate-citric acid buffer solution, a citric acid-sodium citrate buffer solution or an acetic acid-sodium acetate buffer solution; (4) adding chitosan, a piperazine monomer and an anti-pollution additive into the buffer solution, and uniformly conducting stirring to obtain a water-phase solution; (5) mixing trimesoyl chloride and isophthaloyl chloride, adding the mixture into an organic solvent, and uniformly conducting stirring to obtain an oil phase liquid; (6) cutting the porous polysulfone-based membrane, soaking the porous polysulfone-based membrane in the water-phase liquid, and removing the water-phase liquid on the surface of the porous polysulfone-based membrane after soaking; (7) conducting polymerizing in the oil phase liquid after soaking; and (8) after polymerization, conducting drying to obtain the novel charged nanofiltration membrane for organic matter removal.

The invention relates to a pharmaceutical composition for treating serotonergic neurotransmission related disease or condition, including an effective amount of a chlorophenylpiperazine derived compound of Formula (I),

or the pharmaceutically acceptable salt thereof. The pharmaceutical composition is safe and does not have side effect on lethargy.

The invention discloses bis-fluoroquinolone thiadiazole urea N-methyl enoxacin derivatives as well as a preparation method and an application thereof. The general chemical structure formula of the derivatives is shown in the formula I as follows in the description. In the formula I, R is ethyl, cyclopropyl, fluoroethyl, an oxazine ring consisting of C-8 or a thiazine ring consisting of C-8; L is an independent Cl or F atom, 1-piperazinyl or substituted piperazine-1-yl or a nitrogen fused heterocyclic ring; X is CH, N or F-substituted C atom (F-C) or a methoxy substituted C atom (CH3O-C). The bis-fluoroquinolone thiadiazole urea N-methyl enoxacin derivatives realize organic combination of a bis-fluoroquinolone skeleton and the thiadiazole heterocyclic ring with functional urea pharmacophores, so that transition and superposition of different pharmacophores are realized, anti-tumor activity and selectivity of fluoroquinolone are increased, toxic and side effects on normal cells are reduced, and the derivatives can be taken as an anti-tumor active substance for developing anti-tumor drugs with novel structures.

The invention provides a continuous hydrogenation method of ethyl pyrazine-2-carboxylate. The continuous hydrogenation method comprises the following steps: dispersing a mixture of ethyl pyrazine-2-carboxylate and hydrogen to form a gas-liquid mixture containing small liquid drops with sizes of 50 nm-5 mm, wherein the gas-liquid mixture is used as a reaction raw material; and continuously inputting the reaction raw material into a fixed bed reactor, carrying out a catalytic hydrogenation reaction, and continuously discharging ethyl pyrazine-2-carboxylate, wherein the fixed bed reactor is divided into at least two temperature control sections along the flowing direction of the material, and the temperature of the latter temperature control section is controlled to be lower than the temperature of the former temperature control section. According to the above forced dispersion process, the reaction raw material can be subjected to high-performance mass transfer in the catalytic hydrogenation reaction process, so the sufficient reaction degree of the reaction raw material is improved, and reaction time is shortened. The fixed bed reactor is subjected to sectional temperature controlalong the flowing direction of the material, so heat accumulation can be effectively removed, a reaction state in the reactor can be effectively controlled, and the yield, purity and product performance stability of a target product, namely ethyl pyrazine-2-carboxylate are improved.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for producing isopropanolamine and 1, 2-propane diamine by cracking 2, 6-dimethyl piperazine. The method comprises the following steps: carrying out a contact cracking reaction on 1, 2, 6-dimethyl piperazine under the action of a Co-Mo-Pd/Al2O3 catalyst to prepare a mixture of isopropanolamine and 1, 2-propane diamine, and carrying out distillation separation to obtain pure isopropanolamine and 1, 2-propane diamine. According to the method for producing isopropanolamine and 1, 2-propane diamine by cracking 2, 6-dimethyl piperazine, the Co-Mo-Pd/Al2O3 catalyst is adopted for cracking reaction, the catalyst has the advantages of high specific surface area, high mechanical strength and good stability, the preparation process is simple, and the catalyst has very high catalytic activity on cracking of 2, 6-dimethyl piperazine.