The invention discloses a novel process for manufacturing leather shoes, which comprises the steps of lasting, napping, adhesive brushing, rubber sheet placement in a die cavity, injection molding and vulcanization molding, wherein before the step of lasting, a rubber sheet and a vamp are stitched together by using a stitching thread, and then the steps of lasting, napping, adhesive brushing, rubber sheet placement in a die cavity, injection molding and vulcanization molding are performed. Compared with traditional mould pressing modes, the process disclosed by the invention has the differences that after the step of adhesive brushing is completed, rubber and the vamp are stitched together by using a stitching thread, then the steps of adhesive brushing and vulcanization are performed, the rubber subjected to vulcanization in the die cavity and the rubber of the original stitching thread are fused into a whole, and then through the adhering action of an adhesive, the strength of the stitching thread is increased, therefore, the adhering strength of the vamp and a rubber sole is greatly improved, and through measuring and calculating, the adhering strength can be increased by more than one time. Meanwhile, the appearance quality of products has no change, and the stitching thread can not be seen from the vamp and inside of a shoe, but a stitching thread is just added in the internal structure of the shoe.