The invention provides a formula of a thermal insulation board special for a refrigeration house. The formula comprises polystyrene foam particles, dispersible latex powder, natural latex, a flame retardant, a foaming agent, a foam stabilizer, nano silicon dioxide, calcium hydroxide, a plasticizer, mica powder, a film-forming agent and color masterbatch. The formula is prepared from the followingraw materials in parts by weight: 1000kg of the polystyrene foam particles, 8-12 kg of the dispersible latex powder, 8-12 kg of the natural latex, 18-22 kg of the flame retardant, 6-8 kg of the foaming agent, 16-20 kg of the foam stabilizer, 10-22 kg of the nano silicon dioxide, 20 kg of the calcium hydroxide, 4-6 kg of the plasticizer, 45-55 kg of the mica powder, 60-70 kg of the film-forming agent and 3 kg of the color masterbatch. The nano silicon dioxide is added in the foaming process, so that the micropore amount is increased, foam holes are closely formed in the surface, the heat conductivity coefficient is reduced, and the fireproof function of the insulation board is improved.