The invention discloses a transient simulation interpolation calculation method for a power electronic circuit. The method comprises the following steps: 1, establishing a state-space equation; 2, starting simulation; 3, updating the state of the switch group, and calculating and storing a parameter matrix; 4, performing iterative solution to obtain a dense output moment tsense and a dense outputstate variable; 5, judging whether a switching action occurs, if yes, setting fsy to be equal to 1 and going to step 7, and otherwise, going to step 6; 6, judging whether fsy is equal to 0, if yes, executing the step 11, and if not, executing the step 9; 7, calculating a switching action moment tinter and a switching action state variable; 8, judging whether the switch state has occurred, if yes,reading the existing data and going to the step 4, and otherwise, going to the step 3; 9, positioning a next simulation step length, calculating a state variable and setting fsy to be equal to 0; 10,judging whether tdens is greater than tinter, if yes, recalculating the dense output state variable, and otherwise, going to the step 11; 11, calculating an output variable; and 12, judging whether the current time is less than the total simulation duration, if yes, going to the step 4, and otherwise, ending the simulation. The method is high in calculation precision.