The invention relates to a pesticide mixing device with a good effect, the pesticide mixing device comprises a base, a support rod, a cross rod, a liquid medicine box, a mixing box, a driving mechanism, a moving mechanism, a sealing mechanism and a stirring mechanism. According to the pesticide mixing device with the good effect, the driving mechanism drives the moving mechanism to intermittently move, and the moving mechanism drives the sealing mechanism to intermittently operate, the pesticide liquid flows out intermittently, the moving mechanism drives the stirring mechanism to operate, the pesticide liquid is stirred, and a better mixing effect is achieved. Compared with an existing pesticide mixing device, online stirring and mixing of the pesticide liquid are achieved through linkage of the sealing mechanism and the stirring mechanism, efficiency is improved, meanwhile, the linkage is of a pure mechanical structure, the stability of the device is improved, the service life of the device is prolonged, quantitative inflow of pesticide is achieved through intermittent opening of the sealing mechanism, the better mixing effect is achieved, and compared with an existing stirring mechanism, the mechanism achieves the better stirring and mixing effect through forward and reverse rotation of all stirring rods and generation of cross flow.