46results about "Pharmaceutical active ingredients" patented technology

The invention involves foam stabilization compositions that rely upon an electrostatic charge interaction. According to the invention, the positively charged class of polymers such as polyethyleneimine (PEI) polymers are used to provide a long range electrostatic interaction with detersive anionic or amphoteric surfactants present in the same. The interaction must be of sufficient character so that the components do not precipitate out, instead causing longer lasting and increased foam production. The system provides an environmentally friendly alternative for traditional foaming enhancers such as cocamide DEA.

The invention relates to a preparation of and compound injection formed by ª‰-lactam antibiotics and it and its application, which belongs to chemical chemical tragacanth . Make intosodium salt and kali salt, combined with ª‰-lactam antibiotics thy are then changes into powder injection; which can intravenous injection or intravenous drip with ª‰-lactam antibiotics at the sametime. It can remarktably increase the square below the curve, prolong half life of blood elimination (t1/2ª‰) of antibiotics, and the period of medicine density of ª‰-lactam antibiotics in blood surpassing that of the corresponding germ MIC; it can also reduce abuse of antibiotics, avoid generation and development of bacterial strain tolerant to medicine, has good safety and curative effect, stable quality and convenient use.

The instant disclosure relates to hair coloring base compositions and developer compositions that can be incorporated into a hair color cartridge, which combines the compositions and dispenses them onto hair. The hair color cartridge includes: (a) one or more hair coloring base compositions and; (b) one or more developer compositions, which can be combined to form an active hair coloring composition and dispensed onto hair. The hair coloring base compositions typically include one or more oxidative dye precursors; one or more alkalizing agents; one or more reducing agents; optionally, one or more cationic conditioning polymers; one or more surfactants; one or more water-soluble solvents; and water. The developer compositions typically include one or more oxidizing agents; one or more surfactants; and water. The unique components and fluid characteristics of the various compositions are such that devices or appliances comprising them accurately combine and dispense the hair coloring base composition(s) with the developer composition(s) in a predetermined ratio with excellent consistency for application to hair.

The invention belongs to the technical field of medicaments and provides a medicinal composition which separately adopts difluorochloromethane without environmental destruction as a propellant. The medicinal composition not only substitutes dichlorodifluoromethane commonly called Freon 12 with environmental destruction which is often used in pharmaceutical production, but also avoids the problems of the increased cost and complicated processing technology brought by mixing various propellants. Due the adoption of the propellant for proportioning, the aerosol composition has the advantages of controllable pressure in a wide range, simple production technology, easy operation and capacity of completely meeting the requirement on the dichlorodifluoromethane substitute.

The invention relates to an acne-removing conditioner, an acne-removing mask composition and a preparation method of the acne-removing conditioner and the acne-removing mask composition. The acne-removing conditioner is prepared from the following components of 10 to 20 parts of calamine, 0.1 to 2 parts of coated salicylic acid, 0.001 to 0.01 part of oligopeptide-1, 0.001 to 0.01 part of palmitoyl tripeptide-8 and 0.1 to 10 parts of nicotinamide. The acne-removing mask composition is prepared from the components in parts by weight: 50 to 95 parts of aqueous matrix and 5 to 25 parts of oil gel, wherein the water aqueous matrix comprises the acne-removing conditioner and a gel thickening agent; the oil gel comprises grease and a cross-linking agent. According to the acne-removing conditioner, the acne-removing mask composition and the preparation method of the acne-removing conditioner and the acne-removing mask composition, the aqueous matrix and the oil gel are separately stored and are mixed during use, and then the mixture is smeared on the face for use, so that a formed film can be stripped, and a product has the advantages of good skin fitting property, no sensitization and irritation and convenience in use; the preparation method of the acne-removing mask composition is simple and easy to implement, raw materials are easy to obtain, the corresponding aqueous matrix and the oil gel can be separately stored and mixed during use, and the acne-removing mask composition is suitable for large-scale production.

The invention discloses an acne treatment gel with an acne treatment composition. The acne treatment gel consists of the following raw materials in parts by weight: 35-45 parts of a grease expelling mixture, 15-25 parts of nicotinamide, 1-10 parts of ACSD (coupled salicylic acid), 10-20 parts of a traditional Chinese medicine active mixture, 10-20 parts of mint alcohol lactate and 1-6 parts of dipotassium glycyrrhizinate. Epidermis micro-ecological conditions and pH values can be regulated, and most acne-resulted harmful florae are not easy to multiply or grow; sebaceous gland activity can be rapidly regulated, and water-oil balance of skin can be recovered; inflammation can be prevented and eliminated, and discomfort symptoms can be relieved.

The present disclosure relates to hair-treatment compositions, which are particularly useful for providing styling, hair manageability, hair care, and conditioning properties to hair. The hair-treatment compositions typically include: (a) about 1 to about 3 wt. % of one or more vegetable oils; (b) about 2 to about 4 wt. % of one or more solid fatty alcohols; (c) 1 wt. % or less of one or more nonionic surfactants; (d) one or more non-silicone shine enhancers; (e) one or more amidoamines: (f) one or more acids; and (g) water. The unique combination of ingredients results in a product having a milky appearance and a fluid viscosity. Kits comprising the hair-treatment compositions and methods of treating hair using the hair-treatment compositions are also disclosed.

The invention discloses an antibacterial whitening mouthwash and a preparation method thereof. The antibacterial whitening mouthwash comprises an antibacterial component and a mouthwash matrix component, wherein the antibacterial component comprises 0.05 to 0.5 part of lysozyme, 0.01 to 0.5 part of lauryl arginine ethyl ester hydrochloride, 0.01 to 1 part of dextran anhydrase and 1 to 10 parts ofabelmoschus manihot extract. A substrate component of the mouthwash comprises one or more of an emulsifier, a moisturize, a flavoring, an acid-base conditioner and an essence, and the balance is deionized water. Lysozyme and lauryl arginine ethyl ester hydrochloride are dissolved in a citric acid solution and uniformly stirred; the prepared ingredients are mixed with the emulsifier, moisturizer, flavoring and essence evenly, pH is adjusted, and abelmoschus manihot extract and dextran enzyme are added. The invention makes the synergistic effect between the natural antibacterial agent and the chemical antibacterial agent exist, and the mouthwash produced by the invention has high safety and good antibacterial activity, and can effectively prevent and control the occurrence of dental plaque and oral inflammation.

The invention relates to the technical field of cosmetics, and particularly discloses a velvet lipstick and a preparation method thereof. The lipstick is prepared from the following raw materials in parts by weight: 20-30 parts of grease, 15-20 parts of wax, 10-15 parts of ester, 1-5 parts of a film-forming agent, 1-3 parts of a coloring agent and 2-5 parts of a rice extract, wherein the film-forming agent is one or a composition of more of organic silicon resin, a silica gel mixture and silicon dioxide; and the rice extract is a composition of a rice germ extract and a rice extract. The preparation method of the velvet lipstick comprises the following steps: heating and grinding the grease and the ester, adding the film-forming agent, and continuing grinding to obtain a mixed phase A; stirring the wax after anaerobic heating, adding the coloring agent, conducting grinding and mixing, lowering the temperature to 60-70 DEG C, and adding the rice extract to obtain a mixed phase B; and mixing the mixed phase A and the mixed phase B at the temperature of 60-70 DEG C, carrying out oxygen-free heat preservation for 1 h, and naturally cooling the mixture to room temperature to obtain the lipstick. The lipstick disclosed by the invention can be used for decorating the lip skin of a human body and is excellent in texture.

The invention relates to the technical field of cosmetics, in particular to a skincare cosmetic containing a self-repairing active agent and a preparation method of the skincare cosmetic. The skincare cosmetic containing the self-repairing active agent comprises substances as follows: a herba rhodiolae extract, a saffron extract, protease, cream, rice oil, palm oil, coconut oil and an emulsifier. The herba rhodiolae extract and the saffron extract are emulsified and homogenized with protease, the cream and the rice oil, the self-repairing active agent is obtained and matched with the palm oil, the coconut oil and propylene glycol esters of fatty acids and other substances, and the skincare cosmetic is obtained. The skincare cosmetic has the outstanding advantages as follows: the contained self-repairing active agent has effects of promoting blood circulation, activating collagen synthesis, keeping the skin in a good antioxidant environment and the like, the skin is enabled to be in an active state, skin immunity and regeneration physiological activity are improved, skin elasticity is improved, and the skin is enabled to have the lasting anti-aging characteristic.

The invention discloses an anti-freckle skin care product, which is prepared from the following ingredients including phenylethyl resorcinol, 4-butyl-resorcino, 1-methylhydantoin-2-imide, paeonol, paeonol derivatives and oat alkaloid derivatives. In the skin care product, the phenylethyl resorcinol, the 4-butyl-resorcino, the 1-methylhydantoin-2-imide, the paeonol, the paeonol derivatives and theoat alkaloid derivatives are compounded; the generation of melanin can be effectively inhibited; the pigment sedimentation can be reduced. Meanwhile, through the anti-oxidization capability of the paeonol, the oxidization of ingredients of the phenylethyl resorcinol and the like can be effectively inhibited; the product stability is improved. Through the anti-inflammatory and anti-stabbing-pain effect of the oat alkaloid, the irritation caused by the phenylethyl resorcinol derivatives can be effectively relieved; the product is mild and non-irritative on the skin. Compared with the existing anti-freckle product, the anti-freckle skin care product has the more obvious effect in aspects of freckle removal and whitening. The freckle can be fundamentally removed; the freckle generation can beprevented; the product is mild and non-irritative on the skin.

The invention discloses an anti-aging health care skin care product and a preparation method thereof. The raw material of the skin care product comprises natural active ingredients and auxiliary materials,and the natural active ingredients are composed of phellodendri extracts,cortex dictam extracts,safflower extracts and inonotus obliquus polysaccharide. The anti-aging health care skin care product comprises a specific weight composition of the phellodendri extracts,the cortex dictam extracts,the safflower extracts and the inonotus obliquus polysaccharide,the proportion of each component is controlled,and in addition to giving full play to respective basic functions of each component,the components can synergistically increase efficiency,effectively regulate human endocrine secretion,andfundamentally play an anti-aging role. The skin care product has excellent anti-aging effects and is suitable for people whose skin is prone to aging.

The invention discloses a lip-care composition and a preparation method thereof. The lip-care composition comprises effective components including, by weight, 50-80 parts of C10-30 acid cholesterol/lanosterol mixed ester, 1-40 parts of vegetable oil and 5-25 parts of wax. The preparation method of the lip-care composition includes steps: mixing, to be specific, heating and dissolving wax, adding vegetable oil, mixing, heating to 75-90DEG C, and keeping the temperature for at least 30min to obtain a premix; mixed ester adding, namely adding the C10-30 acid cholesterol/lanosterol mixed ester into the premix, and mixing to obtain the lip-care composition. Due to high content of the C10-30 acid cholesterol/lanosterol mixed ester, the chemical structure of the lip-care composition is similar tothat of skin sebum, high hydrophilicity is realized, a stratum corneum not sticky to human skin is formed on the skin, regulation of skin moisture content and skin barrier function can be realized, and a high value in dry skin care is achieved.

The present invention relates to a water-releasing stick-type cosmetic and, specifically, to a water-releasing stick-type cosmetic containing: an oily portion; and a water-releasing ingredient that is spread out in the oily portion, wherein the water-releasing ingredient has water particles encompassed by a plurality of plate-shaped materials to which emulsifiers are bound. According to the present invention, provided is a water-releasing stick-type cosmetic, which can provide a moist and cool feeling by directly supplying a large quantity of water, has excellent dosage form stability by having a hardness suitable for stick cosmetics, and simultaneously has excellent application texture, excellent storage stability and excellent color tone.

The invention discloses a repairing eye cream. The repairing eye cream contains the following raw materials in parts by weight: 35-40 parts of cyclopentasiloxane, 24-28 parts of recombinant hirudin, 15-20 parts of a repairing agent, 1-3 parts of hydroxydecyl ubiquinone, 8-10 parts of an aloe extracting solution, 5-7 parts of butanediol and 30-40 parts of water. The repairing eye cream has excellent preservation stability and good repairing effect and is capable of effectively moistening eye skin, fading eye microgrooves and black eyes and eliminating fat granules.

The present invention relates to a surface-modified ultraviolet blocking powder obtained by reacting an ultraviolet blocking powder including a chloroacetyl group, a phospholipid monomer including an unsaturated bonding, and a catalyst inducing the reaction of the chloroacetyl group and the unsaturated bonding. According to the surface-modified ultraviolet blocking powder of the present invention, the surface may be modified using an effective method, and through chemical bonding (covalent bonding) and as a result of surface modification, the stability of the powder is high. In addition, since the surface modification is performed by using a biocompatible component, the ultraviolet blocking composition including the surface-modified ultraviolet blocking powder may provide ultraviolet blocking properties and biocompatibility at the same time.

The invention belongs to the technical field of membrane separation, and relates to a refining and extracting filtering preparation process of dextran. The method comprises the steps of: first, filtering a crude product liquor of dextran by a micro-filtration membrane; second, filtering the filtrate in the first step by a first ultrafiltration membrane; and third, filtering the filtrate in the second step by a second ultrafiltration membrane, wherein trapped fluid is the refined dextran, the mean pore size of the first ultrafiltration membrane is 20-100nm, and the mean pore size of the second ultrafiltration membrane is 2-20mn or the molecular weight cut-off is 3-100kDa. According to the invention, the membrane separation technology and the pharmaceutical process are combined to filter and refine a dextran raw material, so that a dextran product with narrower distribution of molecular weight is high in purity, is safe and reliable in curative effect and has high economic and beneficial benefits, and the product quality is improved.

The invention discloses a facial mask added with peony extract and a preparation method thereof. The facial mask is prepared from the following raw materials: peony extract, nicotinamide, inositol, oil-soluble vitamin E, an emulsifier, chrysanthellum indicum, honeysuckle flower, pseudo-ginseng root, eucommia bark, glycerin, low-molecular hyaluronic acid, an antibacterial agent and deionized water. According to the invention, substances like a peony flower stock solution, peony seed oil, chrysanthellum indicum, inositol, low-molecular hyaluronic acid, honeysuckle flower and pseudo-ginseng root are mixed to form a compound, so the whitening and skin-tendering facial mask suitable for modern women is formed; and the facial mask can effectively improve the antioxidant capacity of skin, injects sufficient moisture into skin, prevents moisture in the stratum corneum of skin from evaporating, enables loaded plant essence to be easily absorbed, maintains the face to be moist, has good whitening and repairing effects, can effectively remove free radicals in skin, prevents accelerated aging of facial skin, reduces facial wrinkles and has ideal antioxidation and skin aging delaying effects.

The invention provides a kudzuvine root-containing facial mask and a preparation method thereof. Compared with the prior art, the whitening and moisturizing effects of the kudzuvine root-containing facial mask are more superior. A compound plant extract of the kudzuvine root-containing facial mask is compounded through multiple Chinese herbal medicines, an alcohol extract obtained through extraction by means of ethyl alcohol with the concentration of 60% at the temperature ranging from 65 DEG C to 70 DEG C and a kudzuvine root extract are jointly used, the moisturizing and whitening effects of the kudzuvine root extract can be significantly improved, and especially after the compound plant extract prepared through the technology and the kudzuvine root extract are mixed according to the ratio of 1:1, the tyrosinase inhibition rate is further increased, and the moisturizing effect is further improved.

The invention discloses a cosmetic dressing composition based on marine organisms and a preparation method of the composition. The composition comprises the following raw materials in parts by weight:106-116 parts of sea lettuce, 49-88 parts of scytosiphon lomentaria, 12-19 parts of hyaluronic acid, 4-9 parts of ganoderma lucidum polysaccharide, 2-4 parts of oleanolic acid, 13-18 parts of sapindus saponin, 10-20 parts of cocoamidopropyl betaine, 8-11 parts of calendula extract, 3-5 parts of sodium carboxymethyl cellulose, 11-14 parts of lavender essential oil, 3-6 parts of Vc magnesium phosphate, 25-36 parts of honey and 2-5 parts of dry yeast. The cosmetic dressing composition based on marine organisms is capable of effectively delaying aging.

The invention relates to an application of an up-regulating agent of a homologous recombination repair (HR) or non-homologous end joining (NHEJ) pathway in preparation of a medicament for treating diabetes and preventing diabetic individual tumorigenesis. Inventors find that DSB and DSB repair mechanism damage exist in diabetic human cells and tissue, and confirm that EWS/Fbxw7 repairs damaged DNAby activating the HR pathway and the NHEJ pathway for the first time, and the cell cycle is blocked at G0/G1 phase to facilitate DNA repair; the EWS/Fbxw7 can significantly reduce the excessive activation of PARP in diabetic large blood vessels, microvascular endothelium and retinal nerve tissue; the mechanism that inhibits the excessive activation of the PARP can be related to the activation ofthe HR and NHEJ pathways; and results suggest that the up-regulating agent of the HR or NHEJ pathway can be used to prepare the medicament for alleviating a diabetes mellitus vascular endothelial dysfunction, or strengthening the DNA damage repair, or treating the diabetes mellitus, or preventing diabetic complications, or preventing the diabetic individual tumorigenesis.

The invention discloses an agent for multidimensionally removing freckles and acne marks and evening skin tone. The agent is prepared from, by weight, 0.1-0.2 part of allantoin, 2-6 parts of a turmeric root fermentation extract, 0.05-0.3 part of dipotassium glycyrrhizinate, 2-5 parts of niacinamide, 0.5-2 parts of D-panthenol, 0.05-0.2 part of tea tree oil, 0.1-0.2 part of fullerene and 0.05-0.5 part of oryzanol. Through the composition, the acne mark problem can be solved multidimensionally, and the skin whitening effect can be achieved; in the first dimension, acne is subjected to inflammation diminishing treatment through the anti-inflammation and anti-oxidation effect, and thus acne which grows out is quickly healed; in the second dimension, the transepidermal moisture loss of the skin is reduced, the barrier effect of the skin is repaired, the self-repair capability of the skin is restored, the resistance of the skin is enhanced, and thus the acne occurrence frequency is reduced; in the third dimension, the generation of fatty acid and triglyceride in sebum is reduced, so that pores are shrunk, and the acne occurrence severity is reduced.

The invention discloses a nanocellulose-pectin microcapsule and a preparation method and application thereof. The preparation method includes the following steps that (1) orange nanocellulose is subjected to oxidization with an oxidant, and then is subjected to cationic modified reaction with a modifier to obtain cationic nanocellulose; (2) a dextran solution containing pectin is prepared and recorded as a solution A; and a polyethylene glycol solution containing the cationic nanocellulose is prepared and recorded as a solution B; and (3) following steps (1) or (2) is adopted to prepare and obtain the nanocellulose-pectin microcapsule; (1) a millimeter level microcapsule is prepared through a drop injection method, drops of the solution A are dropped into the solution B, and a millimeter level nanocellulose-pectin microcapsule is obtained after reaction; and (2) a micron level microcapsule is prepared through a microcapsule granulator, the solution A is dropped and sprayed into the solution B, and then reacted in the microcapsule granulator to obtain a micron level nanocellulose-pectin microcapsule. The nanocellulose-pectin microcapsule has good biocompatibility and high biosafety.