21 results about "Aqueous solubility" patented technology

The invention relates to cariprazine tartrate (I), a crystal form, a preparation method therefor and use of cariprazine tartrate for treating schizophrenia and dual-phase type I disorder drugs. The compound provided by the invention is excellent in water solubility, flowability of powder and stability, and is an excellent medicinal form of cariprazine. The formula is shown in the description.

The present invention provides an aqueous porcelain imitating coating material, which comprises the following components, by weight, 20-30 parts of a water-soluble polyvinyl alcohol emulsion, 15-25 parts of titanium dioxide powder, 15-25 parts of calcium carbonate, 0.5-0.7 part of methyl cellulose, 0.3-0.5 part of ethyl cellulose, and 65-75 parts of distilled water. The aqueous porcelain imitating coating material of the present invention has the following technical effects that: the coating material belongs to a high gloss coating material, no brick seam exists after dyeing with the coating material, the whole effect is good, and the coating material has the same characteristics as the characteristics of water resistance, alkali resistance, scrub resistance, and the like of the porcelain tile.

The invention provides a preparation method and application of a chitosan-g-poly(epsilon-caprolactone) derivative drug-loaded nano-micelle. According to the invention, chitosan and a poly(epsilon-caprolactone) derivative provided are used for the drug-loaded nano-micelle; the preparation method is simple in process and convenient in operation; a drug with poor water solubility can be encapsulatedand conveyed, the systemic toxicity of the drug is reduced, the biocompatibility of a carrier is improved, and the curative effect of the drug is improved; and the chitosan-g-poly(epsilon-caprolactone) derivative drug-loaded nano-micelle disclosed by the invention has hydrophobic groups and hydrophilic groups which are easily degraded in a living body, can be used as a novel drug-loaded nano-micelle, has a wide substantive application scope, and has very important practical value for treating tumors.

The invention discloses concrete for a prefabricated part and a preparation method thereof, which relate to the technical field of concrete, and solve the problems that harmful substances such as acidand alkali ions are easy to permeate inwards through tiny gaps and cracks of the concrete, so that the volume of a steel bar is expanded, and the prefabricated part is damaged. The concrete for a prefabricated part comprises the following components in parts by weight: 180-200 parts of Portland cement, 170 to 180 parts of water, 720 to 760 parts of medium sand, 1020 to 1050 parts of broken stone,70 to 80 parts of fly ash, 170 to 190 parts of mineral powder, 3 to 5 parts of a water reducing agent, 2 to 3 parts of a retarder, 4 to 8 parts of an anti-permeability agent, 6 to 10 parts of methylsodium silicate, 5 to 9 parts of triethoxysilane, and 15 to 35 parts of organic silicon water-soluble resin. The concrete for the prefabricated part has excellent chemical corrosion resistance, has agood protection effect on steel bars in the prefabricated part, and is good in overall application effect.

The invention discloses preparation of a water-soluble metal-organic framework composite material and application thereof in detecting the concentration of fluorine ions in water. The preparation comprises the following steps of: preparing a urea solution; adding aluminum trichloride into ultrapure water, carrying out ultrasonic treatment until the aluminum trichloride is completely dissolved, adding 2-aminoterephthalic acid under a stirring condition, and stirring until the 2-aminoterephthalic acid is completely dissolved to obtain a mixed solution; slowly dropwise adding the urea solution into the mixed solution, and stirring to obtain a reaction solution; carrying out heat preservation after the reaction solution is heated, cooling, centrifuging, washing precipitates, and carrying out centrifugal separation to obtain a first product; and dispersing the first product into N, N-dimethylformamide, stirring, carrying out centrifugal separation to obtain a second product, dispersing thesecond product into methanol, stirring, carrying out centrifugal separation, and carrying out vacuum drying to obtain the water-soluble metal organic framework composite material. The composite material is used for detecting the fluorine ion concentration in water. The fluorescent probe prepared by the preparation method has a nanosheet microstructure, is easy to store, and has excellent solubility and good stability in water.

The invention discloses a thermochromic composite material for an intelligent window and a preparation method of the thermochromic composite material, water-soluble CMC is introduced into an aqueous dispersion of PNIPAM or HPC, and the phase change temperature of PNIPAM or HPC is reduced by using the hydrophilicity of CMC; the number of scattering centers of PNIPAM or HPC is increased by utilizing a molecular skeleton formed by CMC in water, the solar energy modulation capability is improved, and the thermal stability of the thermochromic material is enhanced. The method is simple, effective and wide in application prospect.

The invention belongs to the technical field of water-soluble polymer material, and in particular relates to a preparation method of a high-solid content polypropylene papermaking reinforcing agent. According to the method, raw materials such as acrylamide, crylic acid, ammonium persulfate and sodium sulfite are adopted to prepare a papermaking reinforcing agent through an aqueous solution polymerization technology, so that problems of low solid content and poor water solubility in the prior art are solved. By utilizing the preparation method, the polymer molecular weight and solid content are improved, the transportation cost and production cost are effectively lowered, and the obtained product has reinforcing, retension and dispersing effects and good dissolvability and can be completely dissolved in the water after soaking in the water, so that the utilization rate of the product is increased, and the product has a wide market prospect and an obvious economic benefit.

The invention discloses a water-soluble integrated zinc sulfate monohydrate granular fertilizer and a preparation method thereof. The water-soluble integrated zinc sulfate monohydrate granular fertilizer is prepared from the following components in percentage by mass: 0.1 to 6.0 percent of a chelating agent, 0.2 to 0.5 percent of phosphoric acid, 0.2 to 0.5 percent of monopotassium phosphate, 0 to3.0 percent of an adhesive, 1.0 to 5.0 percent of urea and the balance being zinc sulfate monohydrate. The zinc sulfate monohydrate, the chelating agent, the phosphoric acid and the monopotassium phosphate are formulated and chelated, so that on one hand, zinc in the obtained zinc fertilizer is in an organic chelated state, the water solubility is good, and the zinc fertilizer is easier to absorbby soil, so that the fertilizer efficiency of the obtained zinc fertilizer is greatly improved; and on the other hand, the antagonism of zinc and other elements is overcome, the blending property andthe buffering property are improved, the zinc fertilizer and macroelements are applied at the same time, and the zinc fertilizer is more suitable for water and fertilizer integration and modern agriculture.

The invention provides a preparation method of aryl borate, which mainly comprises the following steps: in the presence of a water-soluble free radical initiator, reacting by using water as a solventand aryl sulfonyl chloride and bis(pinacolato)borate as raw materials, extracting the reaction product by using an organic solvent after the reaction is completed, collecting the extract an organic phase, and carrying out reduced pressure distillation to obtain the product aryl borate. By using the water-soluble free radical initiator, water can be used as a reaction solvent; compared with the prior art that acetonitrile, halogenated alkane, ethyl acetate and other organic solvents are used, water is used as a solvent, environmental pollution is reduced, toxicity is reduced, and raw material sources are more economical; in addition, the method has the advantages of mild reaction, simple post-treatment, high yield, high purity and the like, and is very suitable for industrial production.

The invention discloses a ferulic acid derivative as well as a preparation method and application thereof, and belongs to the technical field of medicine research. The target ferulic acid derivative is prepared by acylating chlorination of ferulic acid and further esterification condensation with a serine derivative and lipoic acid condensation product. Wherein the used lipoic acid can eliminate free radicals for accelerating aging and pathopoiesis; the lipoic acid has the characteristics of fat solubility and water solubility, so that the lipoic acid can pass through the whole body, can reach any cell part, and provides comprehensive efficacy for a human body; meanwhile, serine is adopted as a linking part of ferulic acid and lipoic acid, the chiral structure of the serine is utilized, so that the compound has better targeting property, and the serine is a safe substance after in-vivo degradation and has better safety in vivo; the prepared ferulic acid derivative has the characteristics of good nephritis curative effect, high activity, low toxicity to other organs, good druggability and the like.

The invention belongs to the medicine technology field, relates to a new baicalin compound and the application of the new baicalin compound, which precisely relates to the new baicalin compound of general formula (I) for treating cardiocerebral vascular diseases. The compound has excellent water solubility and can be conveniently made into water soluble injection or lyophilized powder for injection combining with acceptable carriers in the pharmacy, which is substantially used in the prevention and treatment of cardiocerebral vascular diseases, Alzheimer diseases, cerebral infarction, cerebral ischemia and other varied diseases caused by cerebral ischemia and so on. In the formula, R3 is H or Alkyl; R1 and R2 are hydroxyethyl (hydroxypropyl or hydroxybutyl) or H, among which at least one of R1 and R2 is the hydroxyethyl (hydroxypropyl or hydroxybutyl).

The invention discloses a sulfonate-containing water-soluble iron carbonyl compound with a structural formula shown in the specification, and also discloses a preparation method thereof. The preparation method comprises the following steps: dissolving Fe3(CO)12 and sodium mercapto-propane sulfonate in an organic solvent, reacting at the temperature of lower than 120 DEG C until the reaction liquid becomes orange red, and separating and purifying to obtain the compound. The invention also discloses a method for slowly releasing CO by using the sulfonate-containing water-soluble iron carbonyl compound, which comprises the following specific operation steps: dissolving the compound in a normal saline solution of heavy water, and adding an anti-inflammatory drug solution or an amino acid solution. The compound has good water solubility and moderate stability, it is speculated that a degraded product of the compound has good bio-compatibility from the structure of the compound, no harm or small toxicity is caused to an organism, and the time for releasing carbon monoxide is controllable.

The invention discloses a bio-based concrete workability regulator and a preparation method thereof. The bio-based concrete workability regulator comprises the following components in parts by weight: 30-50% of glycerol, 20-40% of a lignin derivative, 10-15% of reducing sugar, 1-3% of water-soluble polyvinyl alcohol, 1-5% of unsaturated anhydride, 0.5-1.5% of polyisocyanate, 1-4% of unsaturated carboxylic acid, 2-6% of an unsaturated sulfonic acid derivative and 0.8-3% of an initiator. According to the invention, bio-based macromolecules are adopted as raw materials, the use ratio of chemical raw materials is reduced, a plurality of action sites and cross-linked structures are formed by using a polyhydroxy structure and polyfunctionality of natural polymer derivatives, the coating capacity of slurry to aggregate is improved, concrete coating is improved, the segregation and bleeding phenomena of concrete can be effectively improved, the concrete flowability is not influenced, obvious air entraining and retarding side effects are avoided, and the acting effect is lasting and stable.

The invention relates to a microneedle for treating leucoderma as well as a preparation method and application thereof, and relates to the field of medical biological materials. The microneedle comprises hydrogel, a water-soluble substrate material and an active pharmaceutical ingredient, the active pharmaceutical ingredient is selected from at least one of the following raw materials: melanotropin, tofacitinib, tacrolimus, pimerolimus or ruxolitinib. According to the microneedle, hydrogel with high mechanical strength is adopted, the microneedle can pierce the cuticle, the hydrogel is insoluble in water, the prepared microneedle does not need a large amount of organic solvent, after the microneedle pierces the cuticle, the medicine for treating leucoderma is directly delivered to the epidermal layer and the corium layer through the diffusion effect, and the medicine application effect is enhanced; meanwhile, the substrate of the microneedle is made of a water-soluble substrate material, after the skin is punctured by the microneedle, water is absorbed, the tip of the microneedle and the substrate of the microneedle are automatically separated, and the tip which is insoluble in water is remained in the skin, so that active pharmaceutical ingredients attached to the microneedle are released in a long-acting manner, and the administration frequency is reduced.

Provided are: a micro-emulsion which has a small particle diameter of emulsified particles, a narrow particle diameter distribution, improved particle diameter uniformity, and excellent stability; a composition for preparing the micro-emulsion; a method for producing the micro-emulsion; and an application of the micro-emulsion. A microemulsion is prepared using a composition containing, at a prescribed ratio, a surfactant component comprising at least one selected from the group consisting of polysorbate 80 and polyoxyethylated castor oil, an oil, and a poorly water-soluble functional component.

The invention discloses a cutting fluid for a processing center. The cutting fluid comprises the following components in parts by weight: 2-4 parts of triethanolamine, 1-1.5 parts of potassium chloride, 0.5 part of sodium nitrate, 0.3 part of glycerol, 1.6-1.9 parts of sodium nitrite, 0.3 part of a lubricant additive and 92.5-94.3 parts of water. The cutting fluid disclosed by the invention is a water-soluble cutting fluid which is low in cost and transparent, meets the processing needs, and ensures the processing quality of products.